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“Our purpose is to know female reproductive aging, and why fertility quickly declines starting in the mid-30s,” claims Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata is effective.
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Utilizing the GCRLE grant, Munakata and Namekawa will appear additional closely at how oocytes are genomically primed and saved for later use. They may investigate the function of the chromatin remodeler in oocyte survival and fertility.
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The grant from the Global Consortium for Reproductive Longevity and Fairness (GCRLE) was introduced in June. It will supply $two more info hundred,000 in funding, spread above two decades. With it, Munakata will study slightly-recognized aspect of reproductive biology: the best way an egg mobile stops increasing and enters a Keeping sample, suitable throughout the time a female is born.
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This protein might “create and preserve the chromatin point out,” says Namekawa — retaining the spools in place plus the oocytes genetically primed since the mouse matures.
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